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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 4
1996 9
1997 9
1998 15
1999 18
2000 19
2001 24
2002 31
2003 20
2004 25
2005 34
2006 18
2007 15
2008 13
2009 16
2010 23
2011 17
2012 18
2013 18
2014 19
2015 17
2016 13
2017 16
2018 14
2019 10
2020 11
2021 13
2022 1
2023 13
2024 1

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436 results

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Page 1
Exploring the mechanism and experimental validation of Fuzi Lizhong Tang in treating gastric cancer based on network pharmacology and molecular docking.
Zhang FY, Guo SC. Zhang FY, et al. Eur Rev Med Pharmacol Sci. 2023 Oct;27(19):9192-9204. doi: 10.26355/eurrev_202310_33947. Eur Rev Med Pharmacol Sci. 2023. PMID: 37843333 Free article.
GO and KEGG enrichment analysis showed that the mechanism of FZLZT in treating gastric cancer mainly involves cancer, inflammation, metabolism, and blood rheology-related pathways, and may act through 7 core targets (CDKN1A, MYC, MAPK1, MAPK14, RB1, RELA, and STAT3). Molec …
GO and KEGG enrichment analysis showed that the mechanism of FZLZT in treating gastric cancer mainly involves cancer, inflammation, metaboli …
Association between CDKN1A Ser31Arg and C20T gene polymorphisms and colorectal cancer risk and prognosis.
Cacina C, Yaylim-Eraltan I, Arikan S, Saglam EK, Zeybek U, Isbir T. Cacina C, et al. In Vivo. 2010 Mar-Apr;24(2):179-83. In Vivo. 2010. PMID: 20363991
BACKGROUND: CDKN1A (p21(WAF1/CIP1)) plays an important role in cell cycle regulation. ...CDKN1A C20T genotype frequency did not show any significant differences between patients and controls. ...
BACKGROUND: CDKN1A (p21(WAF1/CIP1)) plays an important role in cell cycle regulation. ...CDKN1A C20T genotype frequency did no …
RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-kappaB and p53 transcription factors in cells exposed to high doses of ionizing radiation.
Szołtysek K, Janus P, Zając G, Stokowy T, Walaszczyk A, Widłak W, Wojtaś B, Gielniewski B, Cockell S, Perkins ND, Kimmel M, Widlak P. Szołtysek K, et al. BMC Genomics. 2018 Nov 12;19(1):813. doi: 10.1186/s12864-018-5211-y. BMC Genomics. 2018. PMID: 30419821 Free PMC article.
RESULTS: We identified a subset of radiation-modulated genes whose expression was affected by silencing of both TP53 and RELA, and a subset of radiation-upregulated genes where radiation stimulated binding of both p53 and RelA. For three genes, namely IL4I1, SERPINE1, and CDKN …
RESULTS: We identified a subset of radiation-modulated genes whose expression was affected by silencing of both TP53 and RELA, and a subset …
Crosstalk between KIF1C and PRKAR1A in left atrial myxoma.
Zhou M, Yao Y, Wang X, Zha L, Chen Y, Li Y, Wang M, Yu C, Zhou Y, Li Q, Cao Z, Wu J, Shi S, Jiang D, Long D, Wang J, Wang Q, Cheng X, Liao Y, Tu X. Zhou M, et al. Commun Biol. 2023 Jul 14;6(1):724. doi: 10.1038/s42003-023-05094-5. Commun Biol. 2023. PMID: 37452081 Free PMC article.
Reduction of KIF1C decreases PRKAR1A expression and activates the PKA, which causes an increase in ERK1/2 phosphorylation and SRC-mediated STAT3 activation, a reduction of CDH1, TP53, CDKN1A, and BAX, and eventually promotes tumor formation both in vitro and in vivo. ...
Reduction of KIF1C decreases PRKAR1A expression and activates the PKA, which causes an increase in ERK1/2 phosphorylation and SRC-mediated S …
CRISPR-Cas9-based functional interrogation of unconventional translatome reveals human cancer dependency on cryptic non-canonical open reading frames.
Zheng C, Wei Y, Zhang P, Lin K, He D, Teng H, Manyam G, Zhang Z, Liu W, Lee HRL, Tang X, He W, Islam N, Jain A, Chiu Y, Cao S, Diao Y, Meyer-Gauen S, Höök M, Malovannaya A, Li W, Hu M, Wang W, Xu H, Kopetz S, Chen Y. Zheng C, et al. Nat Struct Mol Biol. 2023 Dec;30(12):1878-1892. doi: 10.1038/s41594-023-01117-1. Epub 2023 Nov 6. Nat Struct Mol Biol. 2023. PMID: 37932451 Free PMC article.
Mechanistically, SMIMP interacts with the ATPase-forming domains of SMC1A, the core subunit of the cohesin complex, and facilitates SMC1A binding to cis-regulatory elements to promote epigenetic repression of the tumor-suppressive cell cycle regulators encoded by CDKN1A an …
Mechanistically, SMIMP interacts with the ATPase-forming domains of SMC1A, the core subunit of the cohesin complex, and facilitates SMC1A bi …
The Effect of Cholesterol in MCF7 Human Breast Cancer Cells.
Albi E, Mandarano M, Cataldi S, Ceccarini MR, Fiorani F, Beccari T, Sidoni A, Codini M. Albi E, et al. Int J Mol Sci. 2023 Mar 21;24(6):5935. doi: 10.3390/ijms24065935. Int J Mol Sci. 2023. PMID: 36983016 Free PMC article.
In MCF7 cells, hypocholesterolemia (1) reduced cell growth, and Ki67 expression; (2) increased ER/PgR expression; (3) stimulated the 3-Hydroxy-3-Methylglutaryl-CoA reductase and neutral sphingomyelinase and; (4) stimulated the expression of CDKN1A gene coding cyclin-depend …
In MCF7 cells, hypocholesterolemia (1) reduced cell growth, and Ki67 expression; (2) increased ER/PgR expression; (3) stimulated the 3-Hydro …
Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity.
Zheng Q, Tang J, Aicher A, Bou Kheir T, Sabanovic B, Ananthanarayanan P, Reina C, Chen M, Gu JM, He B, Alcala S, Behrens D, Lawlo RT, Scarpa A, Hidalgo M, Sainz B Jr, Sancho P, Heeschen C. Zheng Q, et al. J Exp Clin Cancer Res. 2023 Nov 28;42(1):323. doi: 10.1186/s13046-023-02883-y. J Exp Clin Cancer Res. 2023. PMID: 38012687 Free PMC article.
In differentiated cancer cells, NR5A2 promotes cell proliferation by inhibiting CDKN1A. On the other hand, in the CSC population, NR5A2 enhances stemness by upregulating SOX2 through direct binding to its promotor/enhancer region. ...
In differentiated cancer cells, NR5A2 promotes cell proliferation by inhibiting CDKN1A. On the other hand, in the CSC population, NR5 …
436 results